Metabolic tumor profiling with pH, oxygen, and glucose chemosensors on a quantum dot scaffold.
نویسندگان
چکیده
Acidity, hypoxia, and glucose levels characterize the tumor microenvironment rendering pH, pO2, and pGlucose, respectively, important indicators of tumor health. To this end, understanding how these parameters change can be a powerful tool for the development of novel and effective therapeutics. We have designed optical chemosensors that feature a quantum dot and an analyte-responsive dye. These noninvasive chemosensors permit pH, oxygen, and glucose to be monitored dynamically within the tumor microenvironment by using multiphoton imaging.
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ورودعنوان ژورنال:
- Inorganic chemistry
دوره 53 4 شماره
صفحات -
تاریخ انتشار 2014